Achieve calm, clear, healthy-looking skin with Derm #1 ClearBalance Prebiotic Acne Defense Serum—a lightweight, oil-free treatment designed to target adult acne, rosacea-prone skin, redness, and breakouts without irritation.
This next-generation serum helps defend skin against daily environmental stressors and pore-clogging impurities while supporting a balanced, resilient complexion. Powered by patented Prebiotic Activ™ Technology, this plant-based prebiotic—developed by our co-founder, Karen Sinclair Drake—helps maintain a healthy skin microbiome, reducing the conditions that lead to breakouts and inflammation.
Formulated with 1% plant-derived salicylic acid from natural wintergreen, this gentle yet effective acne treatment helps unclog pores, smooth texture, and calm redness—without the dryness, burning, or irritation commonly associated with benzoyl peroxide.
Clinically proven to work faster than leading acne brands, this serum delivers visible results while treating skin with respect.
Helps treat and prevent adult acne & rosacea-related breakouts
Calms redness and irritation
Oil-free, lightweight, non-drying formula
Supports a healthy skin microbiome with patented prebiotics
Powered by 1% natural salicylic acid (benzoyl peroxide–free)
Helps refine texture and improve the look of fine lines
Vegan, cruelty-free, gluten-free
Made with organic & naturally derived ingredients
Planet-friendly, clean beauty formulation
Apply to clean skin morning and night, avoiding the eye area. For best results, use consistently and follow with moisturizer.
Size: 1 fl oz
Salicylic Acid 1% (plant-based, from wintergreen)
Purpose: Acne treatment
Prebiotic Activ™ Technology – supports balanced, healthy skin
Black & White Willow Bark Extracts – natural exfoliation & pore care
Bilberry & Blackcurrant Extracts – antioxidant protection
Pine Needle Extract – prebiotic & detoxifying support
Glycerin & Aloe – hydration & soothing comfort
